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Jonathan M Backer Selected Research

Phosphatidylinositol 3-Kinases (PI 3 Kinase)

1/2019PI3Kβ links integrin activation and PI(3,4)P2 production during invadopodial maturation.
11/2017Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
3/2013Novel approaches to inhibitor design for the p110β phosphoinositide 3-kinase.
1/2013Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.
11/2004Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells.

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Jonathan M Backer Research Topics

Disease

14Neoplasms (Cancer)
01/2019 - 07/2005
7Breast Neoplasms (Breast Cancer)
01/2022 - 11/2004
7Carcinoma (Carcinomatosis)
04/2008 - 08/2004
4Insulin Resistance
11/2017 - 08/2008
3Neoplasm Metastasis (Metastasis)
01/2018 - 12/2007
2Inflammation (Inflammations)
11/2013 - 04/2003
2Congenital Structural Myopathies (Centronuclear Myopathy)
08/2008 - 08/2007
1Pathologic Processes
01/2021
1Fatty Liver
12/2015
1Hyperlipidemias (Hyperlipidemia)
06/2015
1Hypertrophy
01/2015
1Glycogen Storage Disease Type II (Pompe's Disease)
11/2014
1Kyphosis
11/2014
1Carcinogenesis
11/2010
1Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy)
08/2008
1Starvation
09/2005
1Adenocarcinoma
11/2004
1Asthma (Bronchial Asthma)
04/2003

Drug/Important Bio-Agent (IBA)

8Phosphatidylinositols (Phosphatidylinositol)IBA
01/2019 - 07/2005
8Epidermal Growth Factor (EGF)IBA
01/2018 - 08/2004
5Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
01/2019 - 11/2004
5Phosphotransferases (Kinase)IBA
01/2019 - 12/2009
4LipidsIBA
01/2015 - 08/2008
4Phosphoric Monoester Hydrolases (Phosphatases)IBA
03/2013 - 08/2008
3GelatinIBA
01/2022 - 01/2019
3Protein Isoforms (Isoforms)IBA
01/2019 - 11/2004
3Proteins (Proteins, Gene)FDA Link
01/2019 - 03/2008
3G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2019 - 11/2010
3Glucose (Dextrose)FDA LinkGeneric
11/2017 - 09/2005
3Actin Depolymerizing Factors (Cofilins)IBA
12/2007 - 08/2004
2tyrosine receptor (receptor, tyrosine)IBA
01/2019 - 11/2010
2GlycogenIBA
06/2015 - 11/2014
2TensinsIBA
03/2013 - 12/2012
1Calcium-Binding ProteinsIBA
01/2021
1Metalloproteases (Metalloproteinases)IBA
01/2019
1Nonmuscle Myosin Type IIAIBA
01/2018
1Pharmaceutical PreparationsIBA
11/2017
1Sirolimus (Rapamycin)FDA Link
01/2015
1LipofuscinIBA
01/2015
1AcidsIBA
11/2014
1GlucosidasesIBA
11/2014
1Leucine (L-Leucine)FDA Link
11/2014
1Mechanistic Target of Rapamycin Complex 1IBA
11/2014
1Peptides (Polypeptides)IBA
12/2012
1EnzymesIBA
12/2009
1Ribosomal Protein S6 Kinases (S6 Kinase)IBA
08/2008
1Beclin-1IBA
05/2008
1rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA
04/2008
1Wiskott-Aldrich Syndrome ProteinIBA
03/2008
1ForminsIBA
03/2008
1Microfilament Proteins (Actin Binding Proteins)IBA
12/2007
1Chemotactic FactorsIBA
12/2007
1myotubularinIBA
08/2007
1Amino AcidsFDA Link
09/2005
1Type C PhospholipasesIBA
08/2004
1Phospholipases (Phospholipase)IBA
08/2004
1AntigensIBA
04/2003
1Adenosine (Adenocard)FDA LinkGeneric
04/2003